THE PRESS GALLERY

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Eczema Control Plan
Eczema images

Backgrounder

Tuesday, 17 October, 2006
Click to download Researcher backgrounder
THE BRICK WALL MODEL OF THE SKIN
© J Allergy Clin Immunology 2006; 118:3-21. Cork et al.

1: Normal skin
The very top layers of skin are cast off to let new skin come through.

Skin cells (bricks) are held together by binders (iron rods) and lipids (mortar).

 




 

2: Skin prone to eczema
Faulty genes break down the skin barrier’s binders or iron rods much faster than normal.

People with eczema also have gaps in their lipids or mortar.

This results in cracks all the way through the skin barrier.






3: Soap and detergents
Irritants such as soap cause more break down and the “brick wall” starts to fall apart.

 

 






4: Dust mites and bacteria
A broken barrier lets allergens enter the skin easily.

Germs and more irritants then lead to an eczema flare.






 

View the brick wall animation.

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